Suitably designed chiral amino alcohols: Synthesis, resolution and application to the catalytic enantioselective reduction of aryl alkyl ketones

Article abstract of DOI:10.1016/S0957-4166(96)00481-8

The amino alcohol rac-1-(1,2,3,4-tetrahydroisoquinoline-1-yl)-cyclopentanol was resolved via its O,O'-dibenzoyl-tartaric acid salt. These enantiomeric amino alcohols were used in the enantioselective reduction of prochiral aryl alkyl ketones. The resultin