Synthetic Communications p. 1225 - 1231 (2003)
Update date:2022-08-11
Topics:
Czerwinski, Kevin M.
Zificsak, Craig A.
Stevens, John
Oberbeck, Melissa
Randlett, Christopher
King, Melissa
Mennen, Steve
An improved route has been devised which provides canthin-6-one in the highest yield from tryptamine to date. Tryptamine is converted to Nb-benzyltryptamine via reaction with benzoylchloride and reduction using LAH. Pictet-Spengler condensation with 2-ketoglutaric acid, removal of the protecting group by CTH, and aromatization with MnO2 affords canthin-6-one in 48% overall yield.
View Moreguide(suzhou) fine materials co. ltd
Contact:0512-80972173
Address:21st Building, No.369 Lushan Rd, New District Suzhou China 215129
Nanjing Samwon International Limited
Contact:+86-25-84873444
Address:1108, BLDG B, New Century Plaza, No 1, South Taiping Rd.,
Jiaxing Anrui Material Technology Co., Ltd.
Contact:86-573-82651652 13305832579
Address:Room 407, Technology Building, 1369 Chennan Road, Jiaxing City, Zhejiang, China
Hangzhou TJM Chemical Trade Co., Ltd
Contact:86-571-88223276 86-13388481653
Address:2221#,Boyuexuan,1860# Binsheng Road,Binjiang District, Hangzhou CityZhejiang Province, 310051, P. R. China
Shanghai Demand Chemical Co., ltd,China
Contact:86-021-55237578/55239122
Address:Room 3H, No.578, Yingkou Road, Yangpu District, Shanghai, China
Doi:10.1016/j.inoche.2014.05.022
(2014)Doi:10.1246/cl.1994.627
(1994)Doi:10.1248/cpb.38.2960
(1990)Doi:10.1016/S0040-4039(00)87887-9
(1983)Doi:10.1039/ft9928801637
(1992)Doi:10.1002/ejic.202100351
(2021)