ACS Medicinal Chemistry Letters
Letter
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Barbara Morschhaeuser − Phenex Pharmaceuticals AG 69123
Heidelberg, Germany
Floriane Braun − Phenex Pharmaceuticals AG 69123
Heidelberg, Germany
Gerald Kleymann − Phenex Pharmaceuticals AG 69123
Heidelberg, Germany
Thomas Hoffmann − Phenex Pharmaceuticals AG 69123
Heidelberg, Germany
Complete contact information is available at:
Author Contributions
All authors have given approval to the final version of the
manuscript.
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
We would like to thank Christina Sonnek and Dr. Michael
Albers for support and contributions to this work.
■
ABBREVIATIONS
■
ADME, absorption, distribution, metabolism, and excretion;
CYP, cytochrome P450; HLM, human liver microsomes; Kyn,
kynurenine; MLM, mouse liver microsomes; PK, pharmaco-
kinetics; PPB, plasma protein binding; RLM, rat liver
microsomes; SAR, structure−activity relationship; Trp,
tryptophan
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