Synthesis and applications of a new base-labile fluorene derived linker for solid-phase peptide synthesis

DOI: 10.1016/0040-4020(94)01024-T

Source and publish data:

Tetrahedron p. 1449 - 1458 (1995)

Update date:2022-08-11

Topics:

Authors:

Rabanal, Francesc

Giralt, Ernest

Albericio, Fernando

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Article abstract of DOI:10.1016/0040-4020(94)01024-T

The handle N-[(9-hydroxymethyl)-2-fluorenyl]succinamic acid (HMFS) is reported for the preparation of protected peptide segments in combination with a Boc/Bzl protection scheme. Treatment of peptide-resins with morpholine in DMF renders protected peptides in high yields and purities.

Full text of DOI:10.1016/0040-4020(94)01024-T

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