Synthesis and reactions of 11-azaartemisinin and derivatives

DOI: 10.1016/0040-4039(94)02419-C

Source and publish data:

Tetrahedron Letters p. 829 - 832 (1995)

Update date:2022-08-11

Topics:

Authors:

Torok, Daniel S.

Ziffer, Herman

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Article abstract of DOI:10.1016/0040-4039(94)02419-C

11-Azaartemisinin was prepared in 45% yield in a one pot, two-step sequence from the reaction of artemisinin with excess ammonia followed by acid treatment. Analogous reactions of artemisinin with primary alkylamines gave N-alkylazaartemisinins in similar yields.

Full text of DOI:10.1016/0040-4039(94)02419-C

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