Tetrahedron p. 5143 - 5156 (1995)
Update date:2022-08-12
Topics:
Diez
Diez, Anna
Voldoire
Voldoire, Aline
Lopez
Lopez, Isabel
Rubiralta
Rubiralta, Mario
Segarra
Segarra, Victor
Pages
Pages, Lluis
Palacios
Palacios, Jose M.
A general method is described for the synthesis of 3-aminopiperidines from 4-piperidones based on a KOEt treatment of the tosylate of the corresponding oximes (Neber rearrangement). The procedure is applied to the synthesis of N-benzyl-3-amino-4,4-diethoxypiperidine (13), (R)-N-(2-hydroxy-1-phenyl)ethyl analogues 18, and 2-phenyl derivatives 27-28. The methoxybenzylation of the primary amino group of these aminopiperidines leads to a series of potential substance P antagonists.
View More
Shanghai Longjin Metallic Material Co., Ltd.
website:http://www.shlongjin.cn/
Contact:021-56517503,56502257
Address:No.16, Lane 555, Chengyin Road, Shanghai
shijiazhuang alkay chemicals co..ltd(expird)
Contact:86-311-67692035
Address:2601,juntang building,qiaodong district,shijiazhuang
ChangZhou XiaQing Chemical Co., Ltd.
Contact:+86-519-88721665
Address:3# Hengluo Road, Henglin Town, Changzhou City, Jiangsu Province，China
Nanjing Fayekong Chemcial Co.,Ltd(expird)
Contact:86-25-58813444
Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China
SHAANXI FUJIE PHARMACEUTICAL CO.,LTD
website:http://www.fujiepharm.com
Contact:+86-29-63650906
Address:Yuanqu Yi Road, Qinghe Food Industrial Park, Sanyuan County, Shaanxi Province, China
Doi:10.1039/c5cc06595j
(2015)Doi:10.1016/0039-128X(83)90026-0
(1983)Doi:10.1016/j.fitote.2016.10.011
(2016)Doi:10.1016/S0040-4039(99)01050-3
(1999)Doi:10.1016/j.saa.2012.09.019
(2012)Doi:10.1271/bbb1961.46.1711
(1982)
