Tetrahedron p. 5143 - 5156 (1995)
Update date:2022-08-12
Topics:
Diez
Diez, Anna
Voldoire
Voldoire, Aline
Lopez
Lopez, Isabel
Rubiralta
Rubiralta, Mario
Segarra
Segarra, Victor
Pages
Pages, Lluis
Palacios
Palacios, Jose M.
A general method is described for the synthesis of 3-aminopiperidines from 4-piperidones based on a KOEt treatment of the tosylate of the corresponding oximes (Neber rearrangement). The procedure is applied to the synthesis of N-benzyl-3-amino-4,4-diethoxypiperidine (13), (R)-N-(2-hydroxy-1-phenyl)ethyl analogues 18, and 2-phenyl derivatives 27-28. The methoxybenzylation of the primary amino group of these aminopiperidines leads to a series of potential substance P antagonists.
View More
Contact:+44 7958 511245
Address:PO Box 469, Manchester, UK
shandong zhongke taidou chemical co.,ltd
Contact:86-531-88682301
Address:Jinan shandong Province CHina
website:http://www.hanwayschem.com
Contact:+86-18502787239(whatsapp)-
Address:18-1-802, Green Garden, Jianghan District, Wuhan 430023, China
Anyang Double Circle Auxiliary CO.,LTD
Contact:0086-134 6082 4403
Address:dongfeng road, anyang city, henan province,china
Chemvon Biotechnology Co. Ltd.
website:http://www.chemvon.com
Contact:86-21-58550039;86-21-31268550-8004
Address:Suite B-10#, 6999 Chuansha Road, Pudong District, Shanghai 201202, China
Doi:10.1039/c5cc06595j
(2015)Doi:10.1016/0039-128X(83)90026-0
(1983)Doi:10.1016/j.fitote.2016.10.011
(2016)Doi:10.1016/S0040-4039(99)01050-3
(1999)Doi:10.1016/j.saa.2012.09.019
(2012)Doi:10.1271/bbb1961.46.1711
(1982)
