Steroids p. 609 - 616 (1983)
Update date:2022-08-12
Topics:
Lee, Henry J.
Nathoo, Zulfikali M.
The systematic activities of methyl 20-dihydroprednisolonate (1), a new local anti-inflammatory steroid synthesized by modifying the 17β-ketol side-chain of prednisolone, on pituitary-adrenal function and liver glycogen content were investigated in rats.The parent compound, prednisolone, administered intramuscularly, caused a significant dose-related decrease in plasma levels of corticosterone, adrenocorticotropic hormone (ACTH), and liver glycogen content in rats.In contrast, methyl 20-dihydroprednisolonate caused mild PA supression and liver glycogen depletion only at high doses.The steroid acid ester did not exert glycogenic activity, unlike prednisolone, in the adrenalectomized rats.
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Doi:10.1021/ja01645a039
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(2004)
