Steroids p. 609 - 616 (1983)
Update date:2022-08-12
Topics:
Lee, Henry J.
Nathoo, Zulfikali M.
The systematic activities of methyl 20-dihydroprednisolonate (1), a new local anti-inflammatory steroid synthesized by modifying the 17β-ketol side-chain of prednisolone, on pituitary-adrenal function and liver glycogen content were investigated in rats.The parent compound, prednisolone, administered intramuscularly, caused a significant dose-related decrease in plasma levels of corticosterone, adrenocorticotropic hormone (ACTH), and liver glycogen content in rats.In contrast, methyl 20-dihydroprednisolonate caused mild PA supression and liver glycogen depletion only at high doses.The steroid acid ester did not exert glycogenic activity, unlike prednisolone, in the adrenalectomized rats.
View More
Chongqing maohuan Chemicals Co., Ltd
website:http://www.bschem.com
Contact:+86 13996103726
Address:Chongqing Nan'an District Tu Town
Contact:+86-13914766747
Address:Floors 21&22, Jin Cheng Tower, No. 216 Middle Longpan Road, Nanjing
Beijing Mesochem Technology Co.,LTD
website:http://www.mesochem.com
Contact:0086-10-57862036
Address:2301, Floor 23, Building 9 Lippo Plaza, Yard 8 Ronghua Middle Road, ETDZ, Beijing, China
Shanghai Gsyn Chemical Co.,Ltd.
Contact:86-021-67158290
Address:86-021-67158291
Jinan Boss Chemical Industry Co., Ltd.【revoke the business license】
website:http://www.chemboss.com.cn
Contact:+86-531-58591595
Address:No2.Hualong Road, Jinan, China
Doi:10.1021/ja01645a039
(1954)Doi:10.1021/jo00144a037
(1982)Doi:10.1021/acsmedchemlett.9b00613
(2020)Doi:10.1021/j100068a023
(1994)Doi:10.1016/S0009-3084(99)00049-3
(1999)Doi:10.1016/j.tetlet.2004.08.134
(2004)
