Synthesis of 3'-deoxy-3' and 5'-deoxy-5'-[4-(purin-9-yl/pyrimidin-1- yl)methyl-1,2,3-triazol-1-yl]thymidine via 1,3-dipolar cycloaddition

Article abstract of DOI:10.1080/07328319708006135

Synthesis of new 3'-deoxy-3' and 5'-deoxy-5'-[(4-(purin-9-yl/pyrimidin- 1-yl)methyl-1,2,3-Triazol-1-yl]thymidine 8a-g, 10a-g from 3'-azido-3'-deoxy- 5'-O-monomethoxytrityl-thymidine and 5'-azido-5'-deoxythymidine respectively are described. The key step is the 1,3-dipolar cycloaddition between the azido group and N-9/N-1-propargylpurine/pyrimidine derivatives.

Full text of DOI:10.1080/07328319708006135

This article was downloaded by: [University of California Santa Cruz]
On: 11 November 2014, At: 11:04
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered
office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Nucleosides and Nucleotides
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lncn19
Synthesis of 3′-Deoxy-3′ and
5′-Deoxy-5′-[4-(Purin-9-yl/
Pyrimidin-1-yl) methyl-1,2,3-
Triazol-1-yl]thymidine via 1,3-Dipolar
Cycloaddition
a
a
a
a
H. B. Lazrek , M. Taourirte , T. Oulih , Y. Kabbaj , J. L.
b
b
c
c
Barascut , J. L. Imbach , N. A. Almasoudi & W. Pfleiderer
a
Laboratoire de chimie Bio-Orgdnique, Faculté des Sciences ,
Semlalia , Marrakech, Maroc.
b
Laboratoire de chimie Bio-Organique, Faculté des Sciences et
Techniques Montpellier II , France
c
Faculty of Chemistry , Konstanz University , Konstanz,
Germany
Published online: 16 Aug 2006.
To cite this article: H. B. Lazrek , M. Taourirte , T. Oulih , Y. Kabbaj , J. L. Barascut , J. L.
Imbach , N. A. Almasoudi & W. Pfleiderer (1997) Synthesis of 3′-Deoxy-3′ and 5′-Deoxy-5′-[4-
(Purin-9-yl/Pyrimidin-1-yl) methyl-1,2,3-Triazol-1-yl]thymidine via 1,3-Dipolar Cycloaddition,
Nucleosides and Nucleotides, 16:7-9, 1073-1077, DOI: 10.1080/07328319708006135
To link to this article: http://dx.doi.org/10.1080/07328319708006135
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the
“
Content”) contained in the publications on our platform. However, Taylor & Francis,
our agents, and our licensors make no representations or warranties whatsoever as to
the accuracy, completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of the authors,
and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content
should not be relied upon and should be independently verified with primary sources
of information. Taylor and Francis shall not be liable for any losses, actions, claims,
proceedings, demands, costs, expenses, damages, and other liabilities whatsoever
or howsoever caused arising directly or indirectly in connection with, in relation to or
arising out of the use of the Content.

This article may be used for research, teaching, and private study purposes. Any
substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing,
systematic supply, or distribution in any form to anyone is expressly forbidden. Terms
&
Conditions of access and use can be found at http://www.tandfonline.com/page/
terms-and-conditions