3 Substituted 2 formylquinoxaline 1,4 dioxides

Article abstract of DOI:10.1021/jm00240a027

The methylnitrone of 3 methyl 1,4 dioxidoquinoxaline 2 carboxaldehyde (1) has shown exceptional antibacterial activity in vivo. Derivatives of 3 hydroxymethyl 1,4 dioxidoquinoxaline 2 carboxaldehyde and 3 acetoxymethyl 1,4 dioxidoquinoxaline 2 carboxaldehyde were prepared. Several of these compounds were found to be antibacterial agents of the same order of activity as 1.