Deuterium studies in the cyclization and isomerization of 3-propargylmercapto-1,2,4-triazines to thiazolo[3,2-b]-[1,2,4] triazines

Article abstract of DOI:10.1080/10426500008082384

Transformation of 3-propargylmercapto-1,2,4-triazin-5(2H)-one (2; R=H or Me) to the corresponding 2-dihydro-3-methylenethiazolo[3,2-b][1,2,4]triazin-7-one (3; R=H or Me) is performed in a dilute solution of triethylamine in MeOH. Compound (3; R=Me) was isomerized to 3,6-dimethyl-thiazolo[3,2-b][1,2,4]-triazin-5-one (4; R=Me) in 5% aqueous sodium hydroxide. Treatment of (3; R=Me) with 5% sodium deuteroxide gave 6-methyl-3-monodeuterated methyl-2-D-thiazolo[3,2-b][1,2,4]-triazin-7-one (5, R=Me).

Full text of DOI:10.1080/10426500008082384

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Phosphorus, Sulfur, and
Silicon and the Related
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Deuterium Studies in
the Cyclization and
Isomerization of 3-
Propargylmercapto-1,2,4-
Triazines to Thiazolo[3,2-B]-
[1,2,4] Triazines
M. M. Heravi a , M. Shafaie b , P. Khosrofar b &
M. Ghassemzdeh c
a Department of Chemistry , School of Sciences,
Azzahra University Vanak , Tehran, Iran
b Department of Chemistry School of Sciences ,
Ferdowsi University of Mashhad , Iran
c Chemistry & Chemical , Engineering Research
Center of Iran , P.O. Box, 14335-186, Tehran Iran
Published online: 03 Jan 2007.
To cite this article: M. M. Heravi , M. Shafaie , P. Khosrofar & M. Ghassemzdeh
(2000) Deuterium Studies in the Cyclization and Isomerization of 3-
Propargylmercapto-1,2,4-Triazines to Thiazolo[3,2-B]-[1,2,4] Triazines,
Phosphorus, Sulfur, and Silicon and the Related Elements, 167:1, 21-27, DOI:
10.1080/10426500008082384
To link to this article: http://dx.doi.org/10.1080/10426500008082384
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