Synthesis of 3',5'-dithymidylyl-α-hydroxyphosphonate dimer building blocks for oligonucleotide synthesis - A new pro-oligonucleotide approach

Article abstract of DOI:10.1080/07328319708006159

The synthesis of the dimer building blocks 1 and 2 and their introduction into (T)₁₅-oligonucleotides is described. The stability against 3'-exonuclease digestion (SVP) as well as the hybridization properties (T(m) values) were examined.

Full text of DOI:10.1080/07328319708006159

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Synthesis of 3′,5′-Dithymidylyl-α-
hydroxyphosphonate Dimer
Building Blocks for Oligonucleotide
Synthesis—A New Pro-oliguncleotide
Ralf P. Mauritz a , Chris Meier a & Eugen Uhlmann b
a Institute of Organic Chemistry, Johann Wolfgang Goethe-
University , Marie-Curie-Str. 11, D-60439, Frankfurt am Main,
Germany
b Hoechst AG, General Pharma Research G838 , D-65926,
Frankfurt am Main, Germany
Published online: 16 Aug 2006.
To cite this article: Ralf P. Mauritz , Chris Meier & Eugen Uhlmann (1997) Synthesis of
3′,5′-Dithymidylyl-α-hydroxyphosphonate Dimer Building Blocks for Oligonucleotide
Synthesis—A New Pro-oliguncleotide, Nucleosides and Nucleotides, 16:7-9, 1209-1212, DOI:
10.1080/07328319708006159
To link to this article: http://dx.doi.org/10.1080/07328319708006159
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