Synthesis of 2-O-Ethyl Analogues of 3'-Azido- and 3'-Fluoro-2',3'-dideoxyuridines and Evaluation of their Biological Activity against HIV

Article abstract of DOI:10.1007/BF00807175

2-O-Ethyluracil and 2-O-ethylthymine were silylated with 1,1,1,3,3,3-hexamethyldisilazane and condensed in the presence of TMS triflate with 2,3-dideoxy-3-fluoro-D-erythro-pentofuranoside, 3-azido-2,3-dideoxy-D-erythro-pentofuranoside, and 2,3-dideoxy-3-p