Unprecedented Base Effect On the Synthesis of Chiral Phosphinate Esters: A New Route to P-Chiral Phosphine Oxides of High Enantiomeric Purity

Article abstract of DOI:10.1016/S0957-4166(96)00441-7

The stereochemical outcome of the reaction of chiral secondary alcohols with a phosphinyl chloride was found to be highly dependent on the achiral base used.Thus, the reaction of the readily available sugar derived carbinols, 1 and 2, with methylphenylpho