Asymmetric Synthesis of (-)-(2R,6R)-2,6-Dimethylmorpholine

Article abstract of DOI:10.1016/0957-4166(95)00245-K

The title compound was prepared efficiently by O-alkylation of (R)-ethyl lactate with the O-trifluoromethylsulfonyl derivative of (S)-ethyl lactate and further transformations of the two ester functionalities of the homochiral ether thus obtained.