2-[4-(o-methoxyphenyl)piperazin-1-ylmethyl]-1,3-dioxoperhydroimidazo[1 ,5-a]pyridine as a new selective 5-HT(1A) receptor ligand

Article abstract of DOI:10.1016/0960-894X(96)00081-9

A series of 2-[ω-(4-arylpiperazin-1-yl)alkyl]-1,3-dioxoperhydroimidazo[1,5-a]pyri dine derivative was prepared and evaluated for affinity at 5-HT(1A) and α₁ receptors. The most promising analogue 1 m bound at 5-HT(1A) sites with nanomolar affin