Preparation of optically active β-carboxyaspartic acid derivatives via Pd(0)-catalyzed asymmetric substitution of Schiff base acetates

Article abstract of DOI:10.1016/0957-4166(96)00048-1

Optically active β-carboxyaspartic acid derivative 6 (77% ee) was obtained in 48% total yield from the coupling of Schiff base acetate 3 with sodium dimethyl malonate in the presence of 5% Pd(OAc)₂-(2S,4S)-BPPM followed by a single recrystalliz