Bioorganic and Medicinal Chemistry Letters p. 2787 - 2792 (1997)
Update date:2022-08-11
Topics:
Reese, Colin B.
Song, Quanlai
A new approach to the synthesis of oligonucleotides and oligonucleotide phosphorothioates in solution is described; it is based on H-phosphonate coupling at -40°, followed by in situ sulfur-transfer with either N-[(4-chlorophenyl)sulfanyl]phthalimide 19 o
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