Tetrahedron Letters p. 8721 - 8724 (1998)
Update date:2022-08-11
Topics:
Hay, Alastair M.
Hobbs-Dewitt, Sheila
MacDonald, Alasdair A.
Ramage, Robert
The affinity of tetrabenzo[a,c,g,i]fluorene for charcoal has been applied successfully to provide an alternative to existing solid phase synthesis methodology. In a synthesis of the quinolone antibacterial, Ciprofloxacin, traditional solution phase synthesis has been coupled with efficient pseudo-solid phase purification.
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