Use of tetrabenzo[a,c,g,i]fluorene as an anchor group for the solid/solution phase synthesis of ciprofloxacinρ

Article abstract of DOI:10.1016/S0040-4039(98)01918-2

The affinity of tetrabenzo[a,c,g,i]fluorene for charcoal has been applied successfully to provide an alternative to existing solid phase synthesis methodology. In a synthesis of the quinolone antibacterial, Ciprofloxacin, traditional solution phase synthesis has been coupled with efficient pseudo-solid phase purification.