Amino-thiocyanation of electron rich olefins as an efficient purine and pyrimidine N-alkylation process

Article abstract of DOI:10.1081/SCC-120002117

This work describes a relatively simple process to form thiocyanate substituted nucleoside mimics. CISCN is slowly added to a solution of silylated heterocycle and suitable electron rich alkene. N-alkylated heterocycles are isolated in good yields after hydrolytic workup and flash chromatography.