Steroids p. 439 - 444 (1980)
Update date:2022-08-16
Topics:
Dayal, B.
Bagan, E.
Speck, J.
Salen, G.
A convenient procedure for the synthesis of 5β-cholestane-3α,7α,12α,25-tetrol via a modified homologation sequence of the intermediate 3α,7α,12α-triformyloxy-24-oxo-25-diazo-25-homo-5β-cholane involving a homogeneous medium is described.This involves treating the intermediate α-diazoketone in methanol with a solution of silver benzoate in triethylamine.Grignard reaction of the resulting triformyloxy methyl homocholate yielded 5β-cholestane-3α,7α,12α,25-tetrol.Large amounts of this bile alcohol were needed to further investigate the defect of cholic acid biosynthesis in patients with cerebrotendinous xanthomatosis (CTX).
View More
Springchem New Material Technology Co.,Limited
website:http://www.spring-chem.com
Contact:86-21-62885108
Address:602B, Building 1, No. 641, Tianshan Road
Jiangxi Dongxu Chemical Science & Technology Co.,Ltd
Contact:+86-791-86899381
Address:Nanchang, Jiangxi, China
Anhui Eapearl Chemical Co., Ltd.
Contact:86-562-5858458
Address:358 South Huaihe Road
Ji'nan Orgachem Pharmaceutical Co.,Ltd
Contact:+86-531-82687810
Address:Jinan
Contact:86-10-62664360
Address:Building 10,No.18 AnNingZhuang East Road, GuangHua Pioneer Park,HaiDian District, BeiJing China
Doi:10.1166/jnn.2019.16682
(2019)Doi:10.1039/b405347h
(2004)Doi:10.1021/j100462a031
(1980)Doi:10.1016/0022-2852(82)90117-5
(1982)Doi:10.1107/S0108270193011825
(1994)Doi:10.1021/ja01590a034
(1956)
