Journal of Heterocyclic Chemistry p. 145 - 148 (1999)
Update date:2022-08-12
Topics:
Jones, Michael L.
Baccanari, David P.
Tansik, Robert L.
Boytos, Christine M.
Rudolph, Sharon K.
Kuyper, Lee F.
Novel 2,4-diamino-6-methyl-5-ethynylpyrimidines were prepared via palladium catalyzed coupling of 2,4-diamino-5-iodo-6-methyl-pyrimidine with terminal acetylenes. The compounds were inhibitors of dihydrofolate reductase and showed in vitro activity agains
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