Synthesis of 6(α,β)-aminocholestanols as ergosterol biosynthesis inhibitors

Article abstract of DOI:10.1016/S0960-894X(98)00661-1

Δ⁷-5-Desaturase catalyses one of the last steps in ergosterol biosynthesis in fungi. Moreover Δ⁵-unsaturation is necessary for the sparking function. Synthesis of three pairs of C-6 epimeric cholestanol derivatives are described as potential growth inhibitors. Preliminary results suggest that 6β-aminocholestanol is a potent antifungal agent.