Bioorganic and Medicinal Chemistry Letters p. 3627 - 3630 (1998)
Update date:2022-08-17
Topics:
Beuchet, Pierre
El Kihel, Laila
Dherbornez, Michel
Charles, Georges
Letourneux, Yves
Δ7-5-Desaturase catalyses one of the last steps in ergosterol biosynthesis in fungi. Moreover Δ5-unsaturation is necessary for the sparking function. Synthesis of three pairs of C-6 epimeric cholestanol derivatives are described as potential growth inhibitors. Preliminary results suggest that 6β-aminocholestanol is a potent antifungal agent.
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