Bioorganic and Medicinal Chemistry Letters p. 2155 - 2158 (1997)
Update date:2022-08-17
Topics:
David, Bruno
Sevenet, Thierry
Thoison, Odile
Awang, Khalijah
Pais, Mary
Wright, Michel
Guenard, Daniel
Semi-synthesis of derivatives of rhazinilam, an antitubulin compound, delineated some molecular features necessary for biological activity. In the course of this study, the formation of rhazinilam from 1,2-didehydroaspidospermidine is reexamined and a new mechanism is proposed.
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