Hemisynthesis of rhazinilam analogues: Structure - Activity relationships on tubulin-microtubule system

Article abstract of DOI:10.1016/S0960-894X(97)00391-0

Semi-synthesis of derivatives of rhazinilam, an antitubulin compound, delineated some molecular features necessary for biological activity. In the course of this study, the formation of rhazinilam from 1,2-didehydroaspidospermidine is reexamined and a new mechanism is proposed.