A metal-free oxidation of benzo[c]chromen to benzo[c]chromen-6-ones by t-butyl hydroperoxide in the presence of potassium iodide

Article abstract of DOI:10.3987/COM-13-12760

An effective and eco-friendly oxidation method for the synthesis of benzo[c]chromen-6-ones is described. The condition constitutes 6 molar ratio TBHP, catalytic KI and pyridine in acetonitrile as the solvent. Altogether, 16 structurally diverse substituted benzo[c]chromen-6-ones were prepared through this protocol from corresponding benzo[c]chromenes in excellent yields. The Japan Institute of Heterocyclic Chemistry.