Coupling reaction of 4-cyclopentene-1,3-diol monoacetate and lithium alkenylborates and its application to chiral synthesis of prostaglandin intermediates

Article abstract of DOI:10.1016/S0040-4039(97)10655-4

Lithium alkenylborates couple with the monoacetate of 4-cyclopentene-1,3-diol under the nickel catalyst regioselectively and stereospecifically to afford trans 1,3-isomers in good yields. Moreover, an unexpectedly high level of regio-selectivity is observ