1-[ω-(4-arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5-pyrrolidinediones as 5-HT(1A) receptor ligands: Study of the steric requirements of the terminal amide fragment on 5-HT(1A) affinity/selectivity

DOI: 10.1016/S0960-894X(98)00074-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 581 - 586 (1998)

Update date:2022-08-24

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Authors:

Lopez-Rodriguez, Maria L.

Morcillo, M. Jose

Rovat, Tandu K.

Fernandez, Esther

Sanz, Antonio M.

Orensanz, Luis

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Article abstract of DOI:10.1016/S0960-894X(98)00074-2

In the present paper, we report the synthesis and the binding profile on 5-HT(1A), α₁ and D₂ receptors of a new series of imide-arylpiperazines 3. The study of the length of the alkyl chain and the imide substructure allows us to sug

Full text of DOI:10.1016/S0960-894X(98)00074-2

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