1-[ω-(4-arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5-pyrrolidinediones as 5-HT(1A) receptor ligands: Study of the steric requirements of the terminal amide fragment on 5-HT(1A) affinity/selectivity

Article abstract of DOI:10.1016/S0960-894X(98)00074-2

In the present paper, we report the synthesis and the binding profile on 5-HT(1A), α₁ and D₂ receptors of a new series of imide-arylpiperazines 3. The study of the length of the alkyl chain and the imide substructure allows us to sug