A solution-phase combinatorial parallel synthesis of 3β-amido-3α- hydroxy 5α-androstane-17-ones

Article abstract of DOI:10.1016/S0040-4039(98)00772-2

A two-level library of 3β-amido-3α-hydroxy-5α-androstane-17-one compounds was synthesized from a steroid precursor using the solution-phase parallel synthesis. The compounds wore easily obtained in high purity by regioselective aminolysis of the oxirane intermediate followed by acylation of the amine. Since oxiranes can be generated from readily available ketones or alkenes, the proposed strategy give access to a large series of compounds.