Conjugate addition of ammo acid side chains to alkynones and alkynoic acid derivatives

Article abstract of DOI:10.1016/S0040-4020(97)10323-4

Suitably protected amino acids were used to investigate the Michael addition of the sulfanyl group of cysteine, the hydroxyl group of serine and the ε-amino group of lysine to a conjugated alkynone, alkynoic ester and alkynoic amide. The expected heterosu