4-(Cyclic amidino)phenols-preparation and use in a diamidine synthesis

Article abstract of DOI:10.1080/00397910008087126

The Pinner synthesis was applied to the preparation of 4-(cyclic amidino)phenols in high yields from readily available 4-hydroxybenzimidic acid methyl ester hydrochloride and diaminoalkanes. An alternative attempt was made to convert 4-(hydroxy)thiobenzamide to 4-(1,4,5,6-terahydro-5- hydroxy-2-pyrimidinyl)phenol. A procedure for the preparation of 3,6-bis(4- hydroxyphenyl)-1,2,4,5-tetrazine is reported here. The syntheses of 2,4- bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyrimidine and 2-chloro-4-[4- (4,5-dihydro-1H-imidazol-2-yl)-phenoxy]pyrimidine exemplify the use of the title synthetic intermediates.

Full text of DOI:10.1080/00397910008087126

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Synthetic Communications: An
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Organic Chemistry
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4
-
-(Cyclic Amidino)phenols
Preparation and Use In A
Diamidine Synthesis
a
Jaroslaw Spychala
a
Adam Mickiewicz University, Department of
Chemistry, Grunwaldzka 6, 60-780, Poznań, Poland
Version of record first published: 04 Dec 2007.
To cite this article: Jaroslaw Spychala (2000): 4-(Cyclic Amidino)phenols - Preparation
and Use In A Diamidine Synthesis, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 30:6, 1083-1094
To link to this article: http://dx.doi.org/10.1080/00397910008087126
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