Tetrahedron Letters p. 3061 - 3062 (1999)
Update date:2022-08-11
Topics:
Borthwick, Alan D.
Crame, Andy
Exall, Anne
Mason, Andy
Pennell, Andy
An improved synthesis of the 5-Oxo-hexahydro-pyrrolo[3,2-b]pyrrole ring system (Pyrrolidine-5,5-trans-lactam ring system) has been achieved using cyclisation of the amino ethyl ester 4 with t-butyl magnesium chloride in THF to give the translactam 5 in 78
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