NEW AND DIRECT ROUTE TO 5-TRIFLUOROMETHYL-5,6-DIHYDROURACILS BY MEANS OF PALLADIUM COMPLEX CATALYZED "UREIDOCARBONYLATION" OF 2-BROMO-3,3,3-TRIFLUOROPROPENE

Article abstract of DOI:10.1016/S0040-4039(00)88357-4

Palladium complex catalyzed carbonylation of 2-bromo-3,3,3-trifluoropropene (2-Br-TFP) with ureas afforded 5-trifluoromethyl-5,6-dihydrouracils in moderate to good yields, which were converted into 5-trifluoromethyluracils in nearly quantitative yields.