Tetrahedron Letters p. 4099 - 4100 (1982)
Update date:2022-08-17
Topics:
Fuchikami, Takamasa
Ojima, Iwao
Palladium complex catalyzed carbonylation of 2-bromo-3,3,3-trifluoropropene (2-Br-TFP) with ureas afforded 5-trifluoromethyl-5,6-dihydrouracils in moderate to good yields, which were converted into 5-trifluoromethyluracils in nearly quantitative yields.
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