Use of convertible isocyanides for the synthesis of benazepril hydrochloride

Article abstract of DOI:10.1007/s12039-021-01892-8

Herein, we have described a novel and concise synthesis of the potent angiotensin-converting enzyme (ACE) inhibitor, benazepril hydrochloride (7) in trifluoroethanol via an Ugi three-component reaction in shorter reaction times. The key step is the trifluoroacetic acid-mediated hydrolysis of secondary amides (4a and 4b) followed by esterification as a domino process to form corresponding ethyl ester (6). Mainly two universal convertible isocyanides (1a and 1b) were used for the synthesis of benazepril hydrochloride. Graphic abstract: [Figure not available: see fulltext.] Synopsis: An efficient synthesis of benazepril hydrochloride using Ugi three-component reaction.

Full text of DOI:10.1007/s12039-021-01892-8

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Supplementary Information: The online version of this article (https://doi.org/10.1007/s12039-021-01892-8) contains supplementary
material, which is available to authorized users.

3
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