Bioorganic and Medicinal Chemistry Letters p. 3071 - 3076 (1998)
Update date:2022-08-11
Topics:
Antunes, Roberto
Batista, Hildson
Srivastava
Thomas
Araujo
Seven new phthalimide derivatives (9a~g) with 1,2,4-oxadiazol-5-yl methyl group attached to nitrogen have been synthesized from N- phthaloylglycine 6 and arylamidoximes 7a~g. All of these showed potent analgesic effect with acetic acid induced 'writhing' test in mice. One of the better compounds (ID50 = 22 mg/Kg ip) has been found to be 9a which also demonstrates analgesic activity against inflammatory pain.
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