8-Aza-7-deazapurine DNA: Synthesis and duplex stability of oligonucleotides containing 7-substituted bases

Article abstract of DOI:10.1080/07328319908044730

The 7-substituted 8-aza-7-deazapurine phosphoramidites 1a-3c as well as the phosphoramidite 4a were synthesized. In comparison to the parent purine oligonucleotide duplexes, the 7-substituted 8-aza-7-deazapurine residues lead to a significant duplex stabilization.

Full text of DOI:10.1080/07328319908044730

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Nucleosides and Nucleotides
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8-Aza-7-deazapurine DNA: Synthesis
and Duplex Stability of Oligonucleotides
Containing 7-Substituted Bases
F. Seela a , G. Becher a & M. Zulauf a
a Laboratorium für Organische und Bioorganische Chemie, Institut
für Chemie , Universität Osnabrück, Barbarastr. 7, D-49069,
Osnabrück, Germany
Published online: 04 Oct 2006.
To cite this article: F. Seela , G. Becher & M. Zulauf (1999) 8-Aza-7-deazapurine DNA: Synthesis and
Duplex Stability of Oligonucleotides Containing 7-Substituted Bases, Nucleosides and Nucleotides,
18:6-7, 1399-1400, DOI: 10.1080/07328319908044730
To link to this article: http://dx.doi.org/10.1080/07328319908044730
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