Enantioselective synthesis of (+)-presqualene diphosphate

Article abstract of DOI:10.1021/jo00109a026

(+)-(1R,2R,3R)-Presqualene diphosphate (PSPP) is an intermediate in the biosynthesis of squalene from farnesyl diphosphate (FPP). The natural 1R,2R,3R enantiomer was synthesized from farnesol in nine steps with ≥98% ee. The key step in the synthesis was t