Organic Letters
Letter
ability of the N-substituted amino group and, ultimately, the
fluorescence properties of the resulting DHX-hemicyanine fused
NIRfluorophores. Thesimplicityandconcisenessofthistwo-step
synthetic sequence allow an easy exploration of new chemical
spaceandprovideaconvenientstartingpointforthedevelopment
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Experimental procedures, analytical data including H and
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AUTHOR INFORMATION
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Present Address
∥School of Pharmaceutical Science and Technology, Tianjin
University, Building 24, 92 Weijin Road, Nankai District, Tianjin,
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200. (c) Yuan, L.; Lin, W.; Zhao, S.; Gao, W.; Chen, B.; He, L.; Zhu, S. J.
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Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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Tetrahedron 2005, 61, 3097. (b) Song, X.; Johnson, A.; Foley, J. J. Am.
Chem. Soc. 2008, 130, 17652. (c) Lee, J.; Lee, K. H.; Jeon, J.; Dragulescu-
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Sankaran, S.; Kim, J.-Y.; Hariharan, S.; Ahmed, S.; Chang, Y.-T. Chem.
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Financial support for this work was provided by ICES, A*STAR
(
Singapore), Institut Universitaire de France (IUF), the
Burgundy region (“FABER” programme, PARI Action 6, SSTIC
“Imagerie, instrumentation, chimie et applications biomedi-
cales”), and aPHC Merlion grant (2015, 5.04.15). A.R. thanks the
for access to spectroscopy instrumentation. Chematech company
6
́
“
́
(
Dijon, France) is warmly thanked for providing NO2AtBu.
(18) Huang, X.; Anderson, K. W.; Zim, D.; Jiang, L.; Klapars, A.;
Buchwald, S. L. J. Am. Chem. Soc. 2003, 125, 6653.
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