Journal of Pharmacy and Pharmacology p. 585 - 590 (1994)
Update date:2022-08-25
Topics:
Low
Ulgen
Gorrod
Evidence is presented for the formation of N-benzylidene-4-chloroaniline as a metabonate during the metabolism of N-benzyl-4-chloroaniline. Control studies suggest that the diarylimine is formed as a chemical artifact from the debenzylation products (benzaldehyde and 4-chloroaniline). This novel observation indicates a possible pathway to amide formation from N-benzylanilines via diarylimines as intermediates.
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