Nickel-catalyzed asymmetric allylation of alkyl Grignard reagents, effect of ligands, leaving groups and a kinetic resolution with a hard nucleophile

Article abstract of DOI:10.1016/S0040-4039(97)00178-0

Enantioselective addition of Grignard reagents to methyl 1,3-diphenylallyl ether in the presence of Ni(0)-phosphine catalysts is reported. Kinetic resolution (79% ee) observed in the addition of MeMgBr has important implications for the mechanism and further development of this reaction as a valuable synthetic reaction.