OLIGONUCLEOTIDES AND NUCLEOTIDYLPEPTIDES. XXXII. SYNTHESIS AND HYDROLYTIC STABILITY OF AMINO ACID DERIVATIVES OF ADENOSINE 5'-DI(TRI)PHOSPHATES

Article abstract of DOI:10.1007/BF00597810

The synthesis has been effected of the ethyl esters of adenosine -5'-diphospho(P_β --> N)- and adenosine-5'-triphospho(P_γ --> N)-alanine.It has been shown that under the conditions of synthesis the serine analogues of ATP and ADP decompose.An investigation of the hydrolytic stability of the compounds synthesized has shown that they are unstable in acid and alkaline media.In an acid medium the phosphoramide bond is cleaved more rapidly than the phosphoric anhydride bond (in the case of ADP analogue), while in an alkaline medium the ester bond is saponified and the p hosphoric anhydride bond is cleaved.The ATP analogue is more labile both in acid and in alkaline media.