Bioorganic and Medicinal Chemistry Letters p. 459 - 462 (1998)
Update date:2022-08-16
Topics:
Murakarni, Nobutoshi
Umezome, Takashi
Mahmud, Taifo
Sugimoto, Masanori
Kobayashi, Motomasa
Wataya, Yusuke
Kim, Hye-Sook
Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propionyl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.
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