Tetrahedron Letters p. 8215 - 8218 (1997)
Update date:2022-08-24
Topics:
Numata, Atsushi
Iritani, Masashi
Yamada, Takeshi
Minoura, Katsuhiko
Matsumura, Eiko
Yamori, Takao
Tsuruo, Takashi
Pericosines A (1) and B (2), and macrosphelides E - H (3 - 6) have been isolated, along with known macrosphelide C (7), from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai, and their structures have been established on the basis of spectral analyses. Compounds 1 and 2 exhibited significant inhibitory activity in vitro against tumour cells, and the former also showed significant in vivo tumour-inhibitory activity.
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