Cyclic saligenyl phosphotriesters of 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) - A new pro-nucleotide approach

DOI: 10.1016/S0960-894X(96)00597-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 99 - 104 (1997)

Update date:2022-08-31

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Authors:

Meier, Chris

Lorey, Martina

De Clercq

Balzarini, Jan

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Article abstract of DOI:10.1016/S0960-894X(96)00597-5

The synthesis of a new pro-nucleotide approach for d4TMP 2 based on cycloSal-4TMP 3a-d is described. Phosphotriesters 3 release d4TMP 2 selectively by a controlled, chemically induced tandem reaction. CycloSal-phosphotriesters 3 exhibited high biological activity against HIV-1/ HIV-2 in CEM cells which was retained in CEM TK^- cells.

Full text of DOI:10.1016/S0960-894X(96)00597-5

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