Bioorganic and Medicinal Chemistry Letters p. 99 - 104 (1997)
Update date:2022-08-31
Topics:
Meier, Chris
Lorey, Martina
De Clercq
Balzarini, Jan
The synthesis of a new pro-nucleotide approach for d4TMP 2 based on cycloSal-4TMP 3a-d is described. Phosphotriesters 3 release d4TMP 2 selectively by a controlled, chemically induced tandem reaction. CycloSal-phosphotriesters 3 exhibited high biological activity against HIV-1/ HIV-2 in CEM cells which was retained in CEM TK- cells.
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