A short enantioselective synthesis of pipecolic acid

DOI: 10.1016/0957-4166(95)00382-7

Source and publish data:

Tetrahedron Asymmetry p. 2905 - 2906 (1995)

Update date:2022-08-10

Topics:

Authors:

Fernandez-Garcia

McKervey

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Article abstract of DOI:10.1016/0957-4166(95)00382-7

A simple enantioselective route to pipecolic acid is described. The key step involves the Sharpless asymmetric epoxidation of an N-protected aminoheptenol which spontaneously cyclises to a piperidine derivative on deprotection.

Full text of DOI:10.1016/0957-4166(95)00382-7

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