REACTION OF DI(BROMOMAGNESIO)ALKANES WITH UNSYMMETRICALLY SUBSTITUTED CYCLIC ANHYDRIDES

Article abstract of DOI:10.1016/S0040-4039(00)93679-7

Alkylated γ-spirolactones were prepared in one-step reactions in high yields from butane-1,4-diyl and pentane-1,5 diyldimagnesium dibromides and substituted cyclic anhydrides in tetrahydrofuran.In the light of experimental findings electronic and steric factors influence the regiospecificity of this reaction.