ONE-POT SYNTHESIS OF NEW FLUORINATED 4H-1,4-BENZOTHIAZINES AS POSSIBLE ANTICANCER AGENTS

Article abstract of DOI:10.1016/S0022-1139(00)84367-5

One pot synthesis of fluorinated 4H-1,4-benzothiazines can be effected by the condensation and oxidative cyclization of substituted 2-aminobenzenethiols with β-diketone (p-fluorobenzoylacetone) in DMSO.The reaction is believed to proceed via an enamino-ketone system.The structures have been confirmed by their elemental,analyses and spectral studies. p-Fluorobenzoylacetone has been synthesized by Claisen condensation of ethyl acetate with p-fluoroacetophenone.