The Isolation and Absolute Configuration of (1S,2S,3R)-4-Hydroxymethylcyclopent-4-ene-1,2,3-triol: A Putative Intermediate in the Biosynthesis of Aristeromycin by Streptomyces citricolor

Article abstract of DOI:10.1016/S0040-4039(00)60621-4

The novel tetrol 5 has been isolated from cultures of Streptomyces citricolor and shown to have the absolute configuration 1S,2S,3R.Addition of 5 to an aristeromycin non-producing mutant of S. citricolor supported production of both aristeromycin 1 and neplanocin A 2, suggesting that 5 is an intermediate on the biosynthetic pathway.