
Chemical and Pharmaceutical Bulletin p. 163 - 165 (2000)
Update date:2022-08-17
Topics:
Ikeda, Kiyoshi
Konishi, Koji
Sano, Kimihiko
Tanaka, Kiyoshi
The 2-thio- or 2-selenoglycosides of N-acetylneuraminic acid methyl ester were transformed by successive treatment with dimethyl(methylthio)sulfonium triflate (DMTST) and 1,8-diazabicyclo[5.4.0]-7- undecene (DBU) to give the corresponding methyl 2-deoxy-2,3- didehydroneuraminates in excellent yields. Their acids and their analogues are sialidase inhibitors of pharmaceutical interest.
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