
Tetrahedron Letters p. 2621 - 2624 (1992)
Update date:2022-08-11
Topics:
Ruder, Suzanne M.
Acid halides are known to be reductively coupled with aldehydes and ketones in the presence of samarium diiodide to generate α-hydroxy ketones. Low yields coupled product are obtained due to the competitive process of tetrahydrofuran attack on the acid chloride. This competitive reaction can be avoided and yields improved by preparation of samarium diiodide in acetonitrile.
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