Journal of the Chemical Society. Perkin Transactions 2 (2001) p. 2701 - 2706 (1996)
Update date:2022-08-29
Topics:
Awasthi, Satish Kumar
Raghothama, Srinivasa Rao
Balaram, Padmanabhan
The conformational characteristics of three hexapeptides Boc-Leu-Xxx-Val-Leu-Aib-Val-OMe (Xxx - Ala 1, D-Ala 2, Gly 3; Aib = α-aminoisobutyryl) have been probed in CDCl3 solution by NMR methods using solvent perturbation of chemical shifts and radical broadening of NH resonances to delineate intramolecularly hydrogen bonded NH groups. Nuclear Overhauser effects (NOEs) provide additional information on preferred backbone conformations. The substituent at position 2 acts as a major conformational determinant. While a continuous 310 helical conformation is favoured for the peptide with Xxx = Ala, a multiple ss-turns conformation is supported by both NMR and CD data for the peptide with Xxx = D-Ala. In the peptide with Xxx = Gly CD and NMR data suggest that both 310 helical and multiple turns conformations are simultaneously populated. The results suggest that incorporation of D-amino acids and Aib residues into all L-sequences may prove useful in generating sequences containing multiple turns.
View MoreJiYi Chemical (Beijing) Co., Ltd.
Contact:+86-10-89385733
Address:Shilou Town of Fangshan District， Beijing
Suzhou SuKaiLu Chemical Technology Co., Ltd.
Contact:+86-512-62766020
Address:Floor 4, Building 1, Xinyi Pharmaceutical Valley Wisdom Industrial Park, 415 Changyang Street, Suzhou Industrial Park, Jiangsu Province
Sichuan Mianzhu Ronghong Chemical Co.,LTd
Contact:8613981840544
Address:XINSHI INDUSTRY PARK,MIANZHU,SICHUAN,CHINA
Shanghai birch chemical technology co.,ltd
Contact:+86-21-54096810
Address:No.2588,Jungong Road,Shanghai,China
website:http://www.cheminn.com/
Contact:86-531-67875205
Address:No.9-2,South of Shanda Road, Jinan ,China
Doi:10.1039/c4ra10249e
(2015)Doi:10.1039/c0ob00859a
(2011)Doi:10.1016/S0021-9517(03)00084-8
(2003)Doi:10.1002/anie.202000247
(2020)Doi:10.1002/chem.200400187
(2004)Doi:10.1002/hlca.201500273
(2016)
