Tetrahedron Letters p. 289 - 292 (1994)
Update date:2022-08-28
Topics:
Gallagher, Peter T.
Hicks, Terry A.
Lightfoot, Andrew P.
Martin Owton
A novel synthesis of Rhein (2), the active metabolite of the anti-osteoarthritic drug Diacetyl Rhein (1) has been achieved. Key steps include stereospecific olefination of aldehyde 21 with novel phosphonate 28 and the cylisation of acid 31 to produce anthracene 32.
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